Anti-Cancer efficacy of Umbelliferone against Benzo(a)pyrene-induced Lung Carcinogenesis in  Swiss Albino Mice

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Authors :

Sharmila Salam1*, Sathesh Kanna Velli 1, Palanisamy Krishnan1, Indumathi Selvanathan1, Manikandan Murugan1, Nirmala Subramaniam1 and Devaki Thiruvengadam1

Author Address :

1Department of Biochemistry, University of Madras, Chennai-600 025.
*For correspondence E-mail: devakit@yahoo.co.uk

Abstract :

Coumarins and coumarin-related compound are a plentiful source of latent drugs candidate in relation to its protection and effectiveness. The recent study was deliberate to observe the therapeutic result of Umbelliferone (UMB) against Benzo(a)Pyrene induced carcinogenesis in Swiss albino mice. Administration of B(a)P to mice caused in augmented relative lung weight and serum marker enzymes (AHH ,λ-GT and LDH). The levels of lipid peroxides important (in both serum and tissue) with a subsequent reduction in the final body weight and tissue antioxidants like (SOD, CAT, GPx, GR and GST non enzymic antioxidants (GSH, vitamin C, vitamin E and vitamin A).UMB supplementation knowingly reduced these alterations, thereby showing prevailing anticancer effect in lung cancer. Histology examination also clearly showed that UMB significantly inhibited the lung carcinogenesis induced by B(a)P. Based on the results, this study clearly indicates the UMB used as an effective compound against lung carcinogenesis induced by B(a)P.

Keywords :

Lung carcinoma, Umbelliferone, Benzo (a) pyrene, Antioxidant and LPO.

DOI :

Article Info :

Received : July 13, 2018; Accepted : August 28, 2018.

 

   

 

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