Synthesis, characterization and biological studies of transition metal complexes derived from 2-hydroxynaphthoic acid derivatives bearing isatin moiety

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Authors :

Malar Retna A1, Kalaivani S R1 and Joseph J2*

Author Address :

1Department of Chemistry, Scott Christian College, Nagercoil – 629 003, Tamilnadu,
2Department of Chemistry, Noorul Islam Centre for Higher Education, Kumaracoil - 629180, Tamilnadu.
*For correspondence E-mail: iammalar80@gmail.com

Abstract :

Metal (II) (Co(II), Ni(II), Cu(II) and Zn(II)) complexes have been synthesized from the Schiff base ligand derived from 2-hydroxynaphthoic acid derivatives (obtained through esterification reaction followed by the condensation with hydrazine) and 4-nitroisatin. They were characterized using molar conductance, elemental analysis, magnetic susceptibility, FT-IR spectroscopy, electronic spectra, ESR, mass spectra, and powder XRD techniques. All the metal (II) complexes exhibited square planar geometry. The ESR spectra of the copper complex in DMSO solution at 300 and 77 K were recorded and their salient features are reported. The in vitro biological screening effects of the investigated compounds were tested against the bacterial species, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris and Pseudomonas aeruginosa and fungal species, Aspergillus niger, Rhizopus stolonifer, Aspergillus flavus, Rhizoctonia bataicola and Candida albicans by serial dilution method. A comparative study of inhibition values of the Schiff base ligands and their complexes indicated that the complexes showed higher antimicrobial activity than the Schiff base ligands. Superoxide dismutase and antioxidant activities of the metal complexes have also been studied. The electrochemical behavior and “f” factor values indicated that the higher biological activity.

 

Keywords :

Isatin, Biological activity, superoxide, electrochemical behavior

DOI :

Article Info :

Received : June 13, 2018; Accepted : October 28, 2018.

 

   

 

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