Anti-urolithiatic activity of whole plant aqueous and ethanolic extract of Coriandrum sativum L. - an in vitro approach

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Authors :

Sankaranarayanan Chandrasekaran* and Vijayarani Veerasamy

Author Address :

Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar, Tamilnadu-608002
*For correspondence E-mail:

Abstract :

To investigate the anti-urolithiatic activity of aqueous and alcohol extracts of Coriandrum sativum L. by in vitro turbidity and titrimetric assays. Whole plant powder was extracted with alcohol and water. Turbidity and titrimetry methods were carried out to assess the inhibition of calcium oxalate crystal formation and dissolution of crystals respectively by the extracts. The effects of extracts on calcium oxalate crystal formation were also analyzed by light microscopy. Phytochemical screening was carried out in both extracts. The anti-urolithiatic activity of the extracts was compared with standard drug cystone. Phytochemical screening of the aqueous and alcohol extracts of Coriandrum sativum L. revealed the presence of flavonoids, saponins, terpenoids, glycosides and alkaloids. Both the extracts dose dependently (100, 200, 400µg/ml) inhibited the formation of turbidity in nucleation assay. Similarly in a dose dependent manner (10, 50, 100mg/ml) the extracts also dissolved the calcium oxalate crystals. From the results we conclude that the extracts of Coriandrum sativum L. exhibit antiurolithiatic activity. The anti-urolithiatic activity was found to be more significant in the aqueous extract than alcohol extract of Coriandrum sativum.

Keywords :

Urolithiasis; Calcium oxalate crystal; Coriandrum sativum L.; Cystone


Article Info :

Received : January 19, 2018; Accepted : April 16, 2018.




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